RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
mir-378a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
PCR; dual-lucimmunofluorescenceerase reporter assay etc.
Target
NF-KB
Pathway
NF-KAPPA B SIGNALING PATHWAY
PubMed ID
Title
MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression
Year
2016
Function
"Mir-378a-3p inhibits hsc activation by targeting gli3, and its expression is regulated by smo-dependent nf-kb signaling, suggesting that mir-378a-3p has therapeutic potential for hepatic fibrosis."